Nonsyndromic cleft lip and palate: complex genetics and environmental effects

Prescott, NJ; Winter, RM; Malcolm, S; (2001) Nonsyndromic cleft lip and palate: complex genetics and environmental effects. Ann Hum Genet, 65 (Pt 6). pp. 505-15. ISSN 0003-4800 DOI:

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Nonsyndromic cleft lip and palate (CL/P) is a common craniofacial malformation with a complex genetic component. Attempts at identifying susceptibility loci via family and case-control studies have proved inconsistent. It is likely that initial predictions of the complex interactions involved in facial development were underestimated. The candidate gene list for CL/P is getting longer and the need for an impartial, systematic screening technique, to implicate or refute the inclusion of particular loci, is apparent. Large-scale multi-centre collaborations will also be necessary if we are to pursue the avenues of gene-environment interactions, which have opened up over recent years. So we are faced with the question 'Can this complex trait be too complex?'

Item Type: Article
Faculty and Department: Distance Learning
Academic Services & Administration > Distance Learning
PubMed ID: 11851981


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