In vitro susceptibility to closthioamide among clinical and reference strains of Neisseria gonorrhoeae.


Miari, VF; Solanki, P; Hleba, Y; Stabler, RA; Heap, JT; (2017) In vitro susceptibility to closthioamide among clinical and reference strains of Neisseria gonorrhoeae. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00929-17

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Abstract

Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the minimum inhibitory concentrations of closthioamide to be 0.008-0.5 mg/L for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant N. gonorrhoeae.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases
Research Centre: Antimicrobial Resistance Centre (AMR)
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PubMed ID: 28784667
Web of Science ID: 411481800029
URI: http://researchonline.lshtm.ac.uk/id/eprint/4209142

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