Miari, V.F.; Solanki, P.; Hleba, Y.; Stabler, R.A.; Heap, J.T.; (2017) [Accepted Manuscript] In vitro susceptibility to closthioamide among clinical and reference strains of Neisseria gonorrhoeae. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00929-17
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Abstract
Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the minimum inhibitory concentrations of closthioamide to be 0.008-0.5 mg/L for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant N. gonorrhoeae.