The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study


Myint, PK; Smith, RD; Luben, RN; Surtees, PG; Wainwright, NWJ; Wareham, NJ; Bingham, SA; Khaw, KT; (2010) The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study. Journal of clinical epidemiology, 63 (2). pp. 192-198. ISSN 0895-4356 DOI: https://doi.org/10.1016/j.jclinepi.2009.05.002

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Abstract

Objective: To examine the relationship between the Short-Form Six-Dimension (SF-6D) and mortality. Study Design and Setting: Participants were 17,736 men and women aged 40-79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short-Form 36 (SF-36)-item during 1996-2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. The SF-36 data were converted to SF-6D. The relationship between SF-6D and all-cause and cause-specific mortality were examined. Results: One thousand and seventy deaths occurred during a total of H 5,255 person years of follow-up (mean 6.5 years). Lower SF-6D was associated with increased risk of all-cause mortality in men and women. A decrease of I standard deviation (0.12 point) in SF-6D was associated with a 35% increase in all-cause mortality (hazards ratio = 1.35; 95% CI: 1.26, 1.45) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, diabetes, smoking, and social class. Similar results were observed for cardiovascular, cancer, and other causes of deaths. Conclusion: Poor health utility measured by the SF-6D predicted increased fisk of all-cause and cause-specific mortality in men and women. The present study provides the first evidence of the sensitivity of the SF-6D in predicting mortality in an apparently healthy population. (C) 2010 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Short-Form 6-Dimension, UK Short-Form 36, Mortality, Health-related, quality of life (HRQoL), Preference-based HRQoL, Utility index, quality-of-life, reported functional health, epic-norfolk, women, men, cohort, sf-36, sf-6d, behaviors, obesity
Faculty and Department: Faculty of Public Health and Policy
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 19682855
Web of Science ID: 274062400015
URI: http://researchonline.lshtm.ac.uk/id/eprint/4097

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