Avoiding Hypothermia, an Intervention to Prevent Morbidity and Mortality From Pneumonia in Young Children


Pio, A; Kirkwood, BR; Gove, S; (2010) Avoiding Hypothermia, an Intervention to Prevent Morbidity and Mortality From Pneumonia in Young Children. The Pediatric infectious disease journal, 29 (2). pp. 153-159. ISSN 0891-3668 DOI: 10.1097/INF.0b013e3181b4f4b0

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Abstract

Observations and experiments in animals and human beings grant plausibility to the hypothesis that hypothermia is a risk factor for pneumonia. Exposure of body to cold stress causes alterations in the systemic and local defenses against respiratory infections, favoring the infection by inhalation of pathogens normally present in the oropharynx. Neonates and young infants with hypothermia have an increased risk of death; however, there is no strong demonstration that hypothermia leads to pneumonia in these children. Studies that properly addressed the problem of confounding variables have shown an association between cold weather and pneumonia incidence. Probably the strongest evidence that supports the plausibility of the hypothesis is provided by the controlled comparison between patients with traumatic brain injury treated with hypothermia and those treated under normal body temperature. The association between exposure to cold and pneumonia is strong enough to warrant further research focused in young children in developing countries.

Item Type: Article
Keywords: pneumonia, exposure to cold, hypothermia, neonatal care, child survival, invasive pneumococcal disease, traumatic brain-injury, birth-weight, infants, streptococcus-pneumoniae, therapeutic hypothermia, pasteurella-haemolytica, developing-countries, temperature control, newborn-infants, air-pollution
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 20135749
Web of Science ID: 274029600013
URI: http://researchonline.lshtm.ac.uk/id/eprint/4095

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