Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004-2006-2011). An Update on Behalf of the Advisory Board of the 3rd, 4th and 5th Watching the Risk Symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011.


Touboul, PJ; Hennerici, MG; Meairs, S; Adams, H; Amarenco, P; Bornstein, N; Csiba, L; Desvarieux, M; Ebrahim, S; Hernandez Hernandez, R; Jaff, M; Kownator, S; Naqvi, T; Prati, P; Rundek, T; Sitzer, M; Schminke, U; Tardif, JC; Taylor, A; Vicaut, E; Woo, KS; (2012) Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004-2006-2011). An Update on Behalf of the Advisory Board of the 3rd, 4th and 5th Watching the Risk Symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovascular diseases (Basel, Switzerland), 34 (4). pp. 290-296. ISSN 1015-9770 DOI: https://doi.org/10.1159/000343145

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Abstract

: Intima-media thickness (IMT) provides a surrogate end point of cardiovascular outcomes in clinical trials evaluating the efficacy of cardiovascular risk factor modification. Carotid artery plaque further adds to the cardiovascular risk assessment. It is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness >1.5 mm as measured from the media-adventitia interface to the intima-lumen interface. The scientific basis for use of IMT in clinical trials and practice includes ultrasound physics, technical and disease-related principles as well as best practice on the performance, interpretation and documentation of study results. Comparison of IMT results obtained from epidemiological and interventional studies around the world relies on harmonization on approaches to carotid image acquisition and analysis. This updated consensus document delineates further criteria to distinguish early atherosclerotic plaque formation from thickening of IMT. Standardized methods will foster homogenous data collection and analysis, improve the power of randomized clinical trials incorporating IMT and plaque measurements and facilitate the merging of large databases for meta-analyses. IMT results are applied to individual patients as an integrated assessment of cardiovascular risk factors. However, this document recommends against serial monitoring in individual patients.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 23128470
Web of Science ID: 313655000005
URI: http://researchonline.lshtm.ac.uk/id/eprint/406611

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