AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway.


Fehr, D; Casanova, C; Liverman, A; Blazkova, H; Orth, K; Dobbelaere, D; Frey, J; Burr, SE; (2006) AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway. Microbiology (Reading, England), 152 (Pt 9). pp. 2809-18. ISSN 1350-0872 DOI: https://doi.org/10.1099/mic.0.28889-0

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Abstract

Aeromonas salmonicida subsp. salmonicida contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The aopP gene was detected in both typical and atypical A. salmonicida isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-kappaB) signalling pathways. AopP inhibits the NF-kappaB pathway downstream of IkappaB kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 16946275
Web of Science ID: 240693600030
URI: http://researchonline.lshtm.ac.uk/id/eprint/3998

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