Diagnostic yield of tuberculosis using sputum induction in HIV-positive patients before antiretroviral therapy [Short communication].
Lawn, SD;
Kerkhoff, AD;
Pahlana, P;
Vogt, M;
Wood, R;
(2012)
Diagnostic yield of tuberculosis using sputum induction in HIV-positive patients before antiretroviral therapy [Short communication].
The international journal of tuberculosis and lung disease, 16 (10).
pp. 1354-7.
ISSN 1027-3719
DOI: https://doi.org/10.5588/ijtld.12.0174
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: Adults (n = 602) enrolling in a South African antiretroviral treatment clinic underwent culture-based screening for tuberculosis (TB), regardless of symptoms. For those unable to spontaneously expectorate a 'spot' sample (n = 124), sputum induction with nebulised hypertonic saline was used to obtain a first sample and also to rapidly obtain a second sample from all patients. Collection of both samples typically took 10-15 min. The prevalence of culture-positive TB was 15.6% (95%CI 12.8-18.8). Spontaneously expectorated spot samples yielded 79.8% of all culture-positive TB diagnoses. The incremental yield from those needing an induced first sample was 5.3% and the yield from induced second samples was 14.9%.
