The Enduring Challenge of Determining Pneumonia Etiology in Children: Considerations for Future Research Priorities


Feikin, DR; Hammitt, LL; Murdoch, DR; O’Brien, KL; Scott, JAG; (2017) The Enduring Challenge of Determining Pneumonia Etiology in Children: Considerations for Future Research Priorities. Clinical infectious diseases , 64 (suppl_3). S188-S196. ISSN 1058-4838 DOI: 10.1093/cid/cix143

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Abstract

Pneumonia kills more children each year worldwide than any other disease. Nonetheless, accurately determining the causes of childhood pneumonia has remained elusive. Over the past century, the focus of pneumonia etiology research has shifted from studies of lung aspirates and postmortem specimens intent on identifying pneumococcal disease to studies of multiple specimen types distant from the lung that are tested for multiple pathogens. Some major challenges facing modern pneumonia etiology studies include the use of nonspecific and variable case definitions, poor access to pathologic lung tissue and to specimens from fatal cases, poor diagnostic accuracy of assays (especially when testing nonpulmonary specimens), and the interpretation of results when multiple pathogens are detected in a given individual. The future of childhood pneumonia etiology research will likely require integrating data from complementary approaches, including applications of advanced molecular diagnostics and vaccine probe studies, as well as a renewed emphasis on lung aspirates from radiologically confirmed pneumonia and postmortem examinations.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 28575369
URI: http://researchonline.lshtm.ac.uk/id/eprint/3928383

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