Chest Radiograph Findings in Childhood Pneumonia Cases From the Multisite PERCH Study


Fancourt, N; Deloria Knoll, M; Baggett, HC; Brooks, WA; Feikin, DR; Hammitt, LL; Howie, SRC; Kotloff, KL; Levine, OS; Madhi, SA; Murdoch, DR; Scott, JAG; Thea, DM; Awori, JO; Barger-Kamate, B; Chipeta, J; Deluca, AN; Diallo, M; Driscoll, AJ; Ebruke, BE; Higdon, MM; Jahan, Y; Karron, RA; Mahomed, N; Moore, DP; Nahar, K; Naorat, S; Ominde, MS; Park, DE; Prosperi, C; Wa Somwe, S; Thamthitiwat, S; Zaman, SMA; Zeger, SL; O’Brien, KL; O’Brien, KL; Levine, OS; Knoll, MD; Feikin, DR; Deluca, AN; Driscoll, AJ; Fancourt, N; Fu, W; Hammitt, LL; Higdon, MM; Kagucia, EW; Karron, RA; LI, M; Park, DE; Prosperi, C; Wu, Z; Zeger, SL; Watson, NL; Crawley, J; Murdoch, DR; Brooks, WA; Endtz, HP; Zaman, K; Goswami, D; Hossain, L; Jahan, Y; Ashraf, H; Howie, SRC; Ebruke, BE; Antonio, M; McLellan, J; MacHuka, E; Shamsul, A; Zaman, SMA; MacKenzie, G; Scott, JAG; Awori, JO; Morpeth, SC; Kamau, A; Kazungu, S; Ominde, MS; Kotloff, KL; Tapia, MD; Sow, SO; Sylla, M; Tamboura, B; Onwuchekwa, U; Kourouma, N; Toure, A; Madhi, SA; Moore, DP; Adrian, PV; Baillie, VL; Kuwanda, L; Mudau, A; Groome, MJ; Mahomed, N; Baggett, HC; Thamthitiwat, S; Maloney, SA; Bunthi, C; Rhodes, J; Sawatwong, P; Akarasewi, P; Thea, DM; Mwananyanda, L; Chipeta, J; Seidenberg, P; Mwansa, J; Wa Somwe, S; Kwenda, G; (2017) Chest Radiograph Findings in Childhood Pneumonia Cases From the Multisite PERCH Study. Clinical infectious diseases , 64 (suppl_3). S262-S270. ISSN 1058-4838 DOI: 10.1093/cid/cix089

Full text not available from this repository.

Abstract

Background. Chest radiographs (CXRs) are frequently used to assess pneumonia cases. Variations in CXR appearances between epidemiological settings and their correlation with clinical signs are not well documented. Methods. The Pneumonia Etiology Research for Child Health project enrolled 4232 cases of hospitalized World Health Organization (WHO)–defined severe and very severe pneumonia from 9 sites in 7 countries (Bangladesh, the Gambia, Kenya, Mali, South Africa, Thailand, and Zambia). At admission, each case underwent a standardized assessment of clinical signs and pneumonia risk factors by trained health personnel, and a CXR was taken that was interpreted using the standardized WHO methodology. CXRs were categorized as abnormal (consolidation and/or other infiltrate), normal, or uninterpretable. Results. CXRs were interpretable in 3587 (85%) cases, of which 1935 (54%) were abnormal (site range, 35%–64%). Cases with abnormal CXRs were more likely than those with normal CXRs to have hypoxemia (45% vs 26%), crackles (69% vs 62%), tachypnea (85% vs 80%), or fever (20% vs 16%) and less likely to have wheeze (30% vs 38%; all P < .05). CXR consolidation was associated with a higher case fatality ratio at 30-day follow-up (13.5%) compared to other infiltrate (4.7%) or normal (4.9%) CXRs. Conclusions. Clinically diagnosed pneumonia cases with abnormal CXRs were more likely to have signs typically associated with pneumonia. However, CXR-normal cases were common, and clinical signs considered indicative of pneumonia were present in substantial proportions of these cases. CXR-consolidation cases represent a group with an increased likelihood of death at 30 days post-discharge.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 28575361
URI: http://researchonline.lshtm.ac.uk/id/eprint/3928338

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
1Hit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item