Suppression of vaccine responses by malaria: insignificant or overlooked?


Cunnington, AJ; Riley, EM; (2010) Suppression of vaccine responses by malaria: insignificant or overlooked? Expert review of vaccines, 9 (4). pp. 409-29. ISSN 1476-0584 DOI: 10.1586/erv.10.16

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Abstract

Malaria is widely reported to suppress immune responses to heterologous antigens, including vaccines, but the evidence base for this assumption is patchy and confusing. Here we review the evidence for malaria-mediated suppression of responses to vaccination and conclude that: there is evidence of impairment of responses to heterologous polysaccharide antigens in children with clinical malaria or asymptomatic parasitemia; there is little evidence of impairment of responses to routine, protein-based childhood vaccine regimens; and the underlying mechanisms of impaired responsiveness, and especially of impaired responses to T-independent polysaccharide antigens, remain unclear. We suggest that, with the possible exception of vaccines against encapsulated bacteria, the benefits of postponing vaccination until a malaria infection has cleared are probably outweighed by the risk of missing opportunities to vaccinate hard-to-reach populations.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
Vaccine Centre
PubMed ID: 20370551
Web of Science ID: 277214200014
URI: http://researchonline.lshtm.ac.uk/id/eprint/3898

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