Sensitivity and specificity of BCG scar reading among HIV-infected children


Van-Dunem, J; de Alencar, LCA; Rodrigues, LC; de Albuquerque, M; Ramos, ME; Ximenes, RAD; (2010) Sensitivity and specificity of BCG scar reading among HIV-infected children. Vaccine, 28 (9). pp. 2067-2069. ISSN 0264-410X DOI: 10.1016/j.vaccine.2009.12.034

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Abstract

BCG scar has been used as an indicator of vaccination with BCG in the past, but the validity of scar among HIV-positive children is still unknown. The validity of BCG scar reading among such children was estimated, using three different gold standards. The sensitivity ranged from 81.3% (95%-CI: 78.0-84.2) to 91.6% (95%-CI: 88.4-94.0), when the gold standards were, respectively, information from the adult responsible for the child and the vaccination card. The specificity ranged from 90.5% (95% Cl: 81.6-95.5) to 94.1% (95% Cl: 87.7-97.4), when the gold standards were, respectively, the vaccination card and information from the adult responsible for the child. Reading of BCG scar was shown to be a good indicator for vaccination in the past, among HIV-infected children. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: BCG vaccine, Sensitivity, Specificity, BCG scar, HIV infection, Children, northern malawi
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
PubMed ID: 20060085
Web of Science ID: 275991300007
URI: http://researchonline.lshtm.ac.uk/id/eprint/3884

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