A study to explore the risk factors for the early onset of cataract in India

Praveen, MR; Shah, GD; Vasavada, AR; Mehta, PG; Gilbert, C; Bhagat, G; (2010) A study to explore the risk factors for the early onset of cataract in India. Eye (London, England), 24 (4). pp. 686-694. ISSN 0950-222X DOI: https://doi.org/10.1038/eye.2009.137

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Purpose The aim of this study was to identify risk factors for the development of cataract in young patients. Settings The study was undertaken at Iladevi Cataract and IOL Research Centre, Ahmedabad, Gujarat, India. Methods In a clinic-based observational study, 340 consecutive patients in the age group of 30-45 years presenting with nuclear, cortical, posterior subcapsular (PSC), mixed, and posterior polar cataract were prospectively studied. A detailed history regarding sunlight exposure, atopy, diabetes, steroid intake, myopia, glaucoma, and uveitis was elicited. Results The mean age of the patients was 40.2 +/- 4.6 years; there were 202 men. The major risk factors were atopy (25.6%), idiopathic (19.1%), high myopia (12.4%), atopy with steroid intake (10.9%), steroid usage (7.4%), sunlight exposure (3.8%), and diabetes mellitus (3.2%). PSC was observed in 53.5% eyes. Multinomial logistic regression revealed that atopy (P = 0.016), steroid usage (P = 0.100), and diabetes mellitus (P = 0.076) documented higher odds for PSC. High myopia (P<0.001) and sunlight exposure (P = 0.003) documented higher odds for nuclear cataract. Conclusion Atopy was found to be the most common risk factor associated with the development of cataract in young individuals. PSC was the predominant type of cataract prevalent in young patients. Eye (2010) 24, 686-694; doi: 10.1038/eye.2009.137; published online 12 June 2009

Item Type: Article
Keywords: presenile cataract, risk factors, age-related cataracts, nuclear sclerotic cataract, beaver dam eye, atopic-dermatitis, ultraviolet-radiation, epidemiologic evidence, dehydrational crises, population, prevalence, exposure
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: The International Centre for Evidence in Disability
International Centre for Eye Health
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 19521430
Web of Science ID: 276701300028
URI: http://researchonline.lshtm.ac.uk/id/eprint/3796


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