Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania.


Armstrong Schellenberg, JR; Shirima, K; Maokola, W; Manzi, F; Mrisho, M; Mushi, A; Mshinda, H; Alonso, P; Tanner, M; Schellenberg, DM; (2010) Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania. The American journal of tropical medicine and hygiene, 82 (5). pp. 772-81. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.2010.09-0207

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Abstract

Intermittent preventive treatment of malaria in infants (IPTi) with sulphadoxine-pyrimethamine shows evidence of efficacy in individually randomized, controlled trials. In a large-scale effectiveness study, IPTi was introduced in April 2005 by existing health staff through routine contacts in 12 randomly selected divisions out of 24 in 6 districts of rural southern Tanzania. Coverage and effects on malaria and anemia were estimated through a representative survey in 2006 with 600 children aged 2-11 months. Coverage of IPTi was 47-76% depending on the definition. Using an intention to treat analysis, parasitemia prevalence was 31% in intervention and 38% in comparison areas (P = 0.06). In a "per protocol" analysis of children who had recently received IPTi, parasite prevalence was 22%, 19 percentage points lower than comparison children (P = 0.01). IPTi can be implemented on a large scale by existing health service staff, with a measurable population effect on malaria, within 1 year of launch.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Public Health and Policy > Dept of Global Health and Development
Research Centre: Malaria Centre
Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 20439954
Web of Science ID: 277406500006
URI: http://researchonline.lshtm.ac.uk/id/eprint/3783

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