Intermittent preventive treatment against malaria: an update.


Gosling, RD; Cairns, ME; Chico, RM; Chandramohan, D; (2010) Intermittent preventive treatment against malaria: an update. Expert review of anti-infective therapy, 8 (5). pp. 589-606. ISSN 1478-7210 DOI: 10.1586/eri.10.36

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Abstract

Intermittent preventive treatment (IPT) against malaria is a malaria control strategy aimed at reducing the burden of malaria in certain high-risk groups, namely pregnant women and children. Three strategies - IPT in pregnancy (IPTp), infants (IPTi) and children (IPTc) - are reviewed here focusing on the mechanism of action, choice of drugs available, controversies and future research. Drugs for IPT need to be co-formulated, long acting, safe and preferably administered as a single dose. There is no obvious replacement for sulfadoxine-pyrimethamine, the most commonly utilized drug combination. All strategies face similar problems of rising drug resistance, falling malaria transmission and a policy shift from controlling disease to malaria elimination and eradication. IPT is an accepted form of malaria control, but to date only IPTp has been adopted as policy.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Malaria Centre
Antimicrobial Resistance Centre (AMR)
Tropical Epidemiology Group
PubMed ID: 20455687
Web of Science ID: 278281000018
URI: http://researchonline.lshtm.ac.uk/id/eprint/3762

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