Screening and preventive therapy for tuberculosis


Marais, BJ; Ayles, H; Graham, SM; Godfrey-Faussett, P; (2009) Screening and preventive therapy for tuberculosis. Clinics in chest medicine, 30 (4). 827-46, x. ISSN 0272-5231 DOI: https://doi.org/10.1016/j.ccm.2009.08.012

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Abstract

The tuberculosis (TB) epidemic is well controlled in most developed countries and the focus in these areas has shifted to TB eradication. Transmission within nonendemic areas is limited and most cases of TB result from reactivation of distant (latent) infection. With adequate resources, wide-scale use of preventive therapy can assist to eliminate the pool of latent infection that is required for TB eradication. In contrast, TB control remains poor in many developing countries, especially those worst affected by poverty and the human immunodeficiency virus (HIV) epidemic. In this review the authors critically assess the approach to TB preventive therapy in children and adults, focus on the underlying treatment rationale, discuss available data and identify issues of concern.

Item Type: Article
Keywords: Antitubercular Agents/*therapeutic use, Disease Outbreaks/prevention & control, Humans, Mass Screening/*methods, Tuberculin Test/*methods, *Tuberculosis/diagnosis/epidemiology/prevention & control, World Health, Antitubercular Agents, therapeutic use, Disease Outbreaks, prevention & control, Humans, Mass Screening, methods, Tuberculin Test, methods, Tuberculosis, diagnosis, epidemiology, prevention & control, World Health
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 19925970
Web of Science ID: 279256200014
URI: http://researchonline.lshtm.ac.uk/id/eprint/3759

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