A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.


Dvorin, JD; Martyn, DC; Patel, SD; Grimley, JS; Collins, CR; Hopp, CS; Bright, AT; Westenberger, S; Winzeler, E; Blackman, MJ; Baker, DA; Wandless, TJ; Duraisingh, MT; (2010) A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (New York, NY), 328 (5980). pp. 910-2. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.1188191

Full text not available from this repository.

Abstract

Clinical malaria is associated with the proliferation of Plasmodium parasites in human erythrocytes. The coordinated processes of parasite egress from and invasion into erythrocytes are rapid and tightly regulated. We have found that the plant-like calcium-dependent protein kinase PfCDPK5, which is expressed in invasive merozoite forms of Plasmodium falciparum, was critical for egress. Parasites deficient in PfCDPK5 arrested as mature schizonts with intact membranes, despite normal maturation of egress proteases and invasion ligands. Merozoites physically released from stalled schizonts were capable of invading new erythrocytes, separating the pathways of egress and invasion. The arrest was downstream of cyclic guanosine monophosphate-dependent protein kinase (PfPKG) function and independent of protease processing. Thus, PfCDPK5 plays an essential role during the blood stage of malaria replication.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Malaria Centre
PubMed ID: 20466936
Web of Science ID: 277618800054
URI: http://researchonline.lshtm.ac.uk/id/eprint/3731

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
416Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item