Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L; Parsa, Afshin; Gao, Xiaoyi; Yang, Qiong; Smith, Albert V; +122 more... O'Connell, Jeffrey R; Li, Man; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Hwang, Shih-Jen; Johnson, Andrew D; Dehghan, Abbas; Teumer, Alexander; Paré, Guillaume; Atkinson, Elizabeth J; Zeller, Tanja; Lohman, Kurt; Cornelis, Marilyn C; Probst-Hensch, Nicole M; Kronenberg, Florian; Tönjes, Anke; Hayward, Caroline; Aspelund, Thor; Eiriksdottir, Gudny; Launer, Lenore J; Harris, Tamara B; Rampersaud, Evadnie; Mitchell, Braxton D; Arking, Dan E; Boerwinkle, Eric; Struchalin, Maksim; Cavalieri, Margherita; Singleton, Andrew; Giallauria, Francesco; Metter, Jeffrey; de Boer, Ian H; Haritunians, Talin; Lumley, Thomas; Siscovick, David; Psaty, Bruce M; Zillikens, M Carola; Oostra, Ben A; Feitosa, Mary; Province, Michael; de Andrade, Mariza; Turner, Stephen T; Schillert, Arne; Ziegler, Andreas; Wild, Philipp S; Schnabel, Renate B; Wilde, Sandra; Munzel, Thomas F; Leak, Tennille S; Illig, Thomas; Klopp, Norman; Meisinger, Christa; Wichmann, H-Erich; Koenig, Wolfgang; Zgaga, Lina; Zemunik, Tatijana; Kolcic, Ivana; Minelli, Cosetta; Hu, Frank B; Johansson, Asa; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H; Wright, Alan F; Campbell, Harry; Ellinghaus, David; Schreiber, Stefan; Aulchenko, Yurii S; Felix, Janine F; Rivadeneira, Fernando; Uitterlinden, Andre G; Hofman, Albert; Imboden, Medea; Nitsch, Dorothea; Brandstätter, Anita; Kollerits, Barbara; Kedenko, Lyudmyla; Mägi, Reedik; Stumvoll, Michael; Kovacs, Peter; Boban, Mladen; Campbell, Susan; Endlich, Karlhans; Völzke, Henry; Kroemer, Heyo K; Nauck, Matthias; Völker, Uwe; Polasek, Ozren; Vitart, Veronique; Badola, Sunita; Parker, Alexander N; Ridker, Paul M; Kardia, Sharon LR; Blankenberg, Stefan; Liu, Yongmei; Curhan, Gary C; Franke, Andre; Rochat, Thierry; Paulweber, Bernhard; Prokopenko, Inga; Wang, Wei; Gudnason, Vilmundur; Shuldiner, Alan R; Coresh, Josef; Schmidt, Reinhold; Ferrucci, Luigi; Shlipak, Michael G; van Duijn, Cornelia M; Borecki, Ingrid; Krämer, Bernhard K; Rudan, Igor; Gyllensten, Ulf; Wilson, James F; Witteman, Jacqueline C; Pramstaller, Peter P; Rettig, Rainer; Hastie, Nick; Chasman, Daniel I; Kao, WH; Heid, Iris M; Fox, Caroline S; (2010) New loci associated with kidney function and chronic kidney disease. Nature genetics, 42 (5). pp. 376-384. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.568
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Abstract
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
| Item Type | Article |
|---|---|
| Keywords | genome-wide association, glomerular-filtration-rate, serum creatinine, alstrom-syndrome, hypertrophic cardiomyopathy, proximal tubule, blood-pressure, protein, gene, expression |
| Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
| Research Centre |
Centre for Global Non-Communicable Diseases (NCDs) The International Centre for Evidence in Disability |
| PubMed ID | 20383146 |
| ISI | 277179500006 |
| Related URLs |
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