%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Hidayat Trimarsanto, Ernest D. Benavente, Rintis Noviyanti, Retno Ayu Setya Utami, Leily Trianty, Zuleima Pava, Sisay Getachew, Jung-Yeon Kim, Youn-Kyoung Goo, Sonam Wangchuck, Yaobao Liu, Qi Gao, Simone Dowd, Qin Cheng, Taane G. Clark, Ric N. Price, Sarah Auburn
VivaxGEN: An open access platform for comparative analysis of short tandem repeat genotyping data in Plasmodium vivax populations
www.plosntds.org
www.plosntds.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/A 23 0 R>>
endobj
23 0 obj
<>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005465.ref001)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005465.ref002)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005465.ref019)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005465.ref020)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0005465.ref021)>>
endobj
22 0 obj
<>/Border[0 0 0]/A 24 0 R>>
endobj
24 0 obj
<>
endobj
15 0 obj
[25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R]
endobj
25 0 obj
<>stream
q
0.955 g
0 w
199.9998 563.6146 m
575.9997 563.6146 l
575.9997 324.6151 l
199.9998 324.6151 l
f*
0.45 0.36 0.35 0.01 k
575.9997 588.6145 m
199.9998 588.6145 l
199.9998 589.1145 l
575.9997 589.1145 l
f*
0.83 0.64 0.02 0 k
307.389 383.5276 m
429.7323 383.5276 l
h
f*
233.348 198.9354 m
238.1102 198.9354 l
h
f*
238.1102 120.926 m
242.8724 120.926 l
h
f*
248.0315 120.926 m
257.5559 120.926 l
h
f*
337.0394 81.9213 m
346.5638 81.9213 l
h
f*
348.8315 81.9213 m
358.2992 81.9213 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(be)Tj
1.3188 0 Td
(formatted)Tj
4.4041 0 Td
(and)Tj
1.8679 0 Td
(exported)Tj
4.064 0 Td
(for)Tj
1.3785 0 Td
(application)Tj
4.9293 0 Td
(in)Tj
0.9847 0 Td
(commonly)Tj
4.7323 0 Td
(used)Tj
2.3632 0 Td
(population)Tj
4.7682 0 Td
(genetic)Tj
3.4075 0 Td
(software)Tj
-34.2185 -1.474 Td
(including)Tj
/F6 1 Tf
4.1057 0 Td
(GENEPOP)Tj
/F0 1 Tf
(,)Tj
/F6 1 Tf
5.4186 0 Td
(Arlequin)Tj
/F0 1 Tf
3.8432 0 Td
(and)Tj
/F6 1 Tf
1.8619 0 Td
(STRUCTURE)Tj
/F0 1 Tf
(.)Tj
6.6241 0 Td
(To)Tj
1.3845 0 Td
(date,)Tj
2.4169 0 Td
(data)Tj
2.1484 0 Td
(from)Tj
2.202 0 Td
(10)Tj
1.3189 0 Td
(countries,)Tj
4.5056 0 Td
(includ-)Tj
-35.8298 -1.474 Td
(ing)Tj
1.5336 0 Td
(5)Tj
0.7639 0 Td
(publicly)Tj
3.509 0 Td
(available)Tj
4.0998 0 Td
(data)Tj
2.1483 0 Td
(sets)Tj
2.035 0 Td
(have)Tj
2.3632 0 Td
(been)Tj
2.4169 0 Td
(shared)Tj
3.2404 0 Td
(with)Tj
1.9753 0 Td
(VivaxGEN.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 647.0929 cm
BT
/F3 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 630.1417 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(VivaxGEN)Tj
4.7979 0 Td
(is)Tj
0.931 0 Td
(well)Tj
1.9156 0 Td
(placed)Tj
3.1211 0 Td
(to)Tj
1.0503 0 Td
(facilitate)Tj
3.8372 0 Td
(regional)Tj
3.7238 0 Td
(overviews)Tj
4.619 0 Td
(of)Tj
/F6 1 Tf
1.0443 0 Td
(P)Tj
/F0 1 Tf
(.)Tj
/F6 1 Tf
1.1578 0 Td
(vivax)Tj
/F0 1 Tf
2.4765 0 Td
(transmission)Tj
5.7708 0 Td
(dynamics)Tj
-34.4453 -1.474 Td
(in)Tj
0.9846 0 Td
(different)Tj
3.7895 0 Td
(endemic)Tj
3.9565 0 Td
(settings)Tj
3.6284 0 Td
(and)Tj
1.8678 0 Td
(capable)Tj
3.6761 0 Td
(to)Tj
1.0444 0 Td
(be)Tj
1.3188 0 Td
(adapted)Tj
3.7895 0 Td
(for)Tj
1.3725 0 Td
(similar)Tj
3.0734 0 Td
(genetic)Tj
3.4015 0 Td
(studies)Tj
3.3539 0 Td
(of)Tj
/F6 1 Tf
1.0443 0 Td
(P)Tj
/F0 1 Tf
(.)Tj
/F6 1 Tf
1.1637 0 Td
(fal-)Tj
-37.4649 -1.474 Td
(ciparum)Tj
/F0 1 Tf
3.7357 0 Td
(and)Tj
1.8679 0 Td
(other)Tj
2.4706 0 Td
(organisms.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 209.9905 545.6125 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Author)Tj
3.137 0 Td
(summary)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 209.9905 527.6409 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(The)Tj
/F13 1 Tf
1.7631 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
5.074 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.279 0 Td
(malaria)Tj
3.1805 0 Td
(parasite)Tj
3.2825 0 Td
(inflicts)Tj
2.8686 0 Td
(significant)Tj
4.3256 0 Td
(morbidity)Tj
4.184 0 Td
(in)Tj
1.0261 0 Td
(endemic)Tj
3.6113 0 Td
(popula-)Tj
-31.5947 -1.3039 Td
(tions)Tj
2.1713 0 Td
(across)Tj
2.6418 0 Td
(the)Tj
1.4514 0 Td
(globe,)Tj
2.5625 0 Td
(but)Tj
1.5307 0 Td
(has)Tj
1.525 0 Td
(been)Tj
2.0976 0 Td
(overshadowed)Tj
5.9017 0 Td
(by)Tj
1.1679 0 Td
(the)Tj
1.4513 0 Td
(more)Tj
2.3188 0 Td
(fatal)Tj
/F13 1 Tf
1.8878 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()9()11()4(\r)1()10()4()16()-9( )12()]TJ
/F7 1 Tf
4.4163 0 Td
(parasite.)Tj
-32.1049 -1.2982 Td
(In)Tj
1.0998 0 Td
(malaria-endemic)Tj
6.9165 0 Td
(regions)Tj
3.1237 0 Td
(outside)Tj
3.0898 0 Td
(of)Tj
1.0034 0 Td
(Africa,)Tj
2.8687 0 Td
(the)Tj
1.457 0 Td
(declining)Tj
3.8834 0 Td
(prevalence)Tj
4.422 0 Td
(of)Tj
/F13 1 Tf
1.0035 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[()9()11()4(\r)1()10()4()16()-9( )12()]TJ
/F7 1 Tf
4.4163 0 Td
(is)Tj
-34.2649 -1.2983 Td
(coupled)Tj
3.3505 0 Td
(with)Tj
1.9729 0 Td
(a)Tj
0.6519 0 Td
(proportionate)Tj
5.709 0 Td
(rise)Tj
1.6157 0 Td
(in)Tj
/F13 1 Tf
1.0262 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9807 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
(,)Tj
2.4945 0 Td
(reflecting)Tj
3.9175 0 Td
(the)Tj
1.4513 0 Td
(greater)Tj
2.965 0 Td
(refractoriness)Tj
5.5842 0 Td
(of)Tj
/F13 1 Tf
1.0035 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9864 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
-33.7093 -1.3039 Td
(to)Tj
1.0147 0 Td
(transmission)Tj
5.2895 0 Td
(interventions.)Tj
5.6806 0 Td
(This)Tj
1.9672 0 Td
(worrying)Tj
3.8381 0 Td
(trend)Tj
2.3584 0 Td
(emphasizes)Tj
4.7111 0 Td
(the)Tj
1.4514 0 Td
(need)Tj
2.1203 0 Td
(for)Tj
1.3663 0 Td
(a)Tj
0.6463 0 Td
(better)Tj
2.5058 0 Td
(under-)Tj
-32.9497 -1.2983 Td
(standing)Tj
3.6226 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4513 0 Td
(patterns)Tj
3.4242 0 Td
(of)Tj
/F13 1 Tf
1.0035 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.279 0 Td
(transmission)Tj
5.2894 0 Td
(and)Tj
1.7121 0 Td
(spread)Tj
2.8233 0 Td
(within)Tj
2.7723 0 Td
(and)Tj
1.7178 0 Td
(across)Tj
2.6362 0 Td
(borders.)Tj
-30.716 -1.2982 Td
(Genotyping)Tj
4.9095 0 Td
(parasite)Tj
3.2769 0 Td
(population)Tj
4.5297 0 Td
(samples)Tj
3.3392 0 Td
(at)Tj
0.9411 0 Td
(short)Tj
2.2563 0 Td
(tandem)Tj
3.2372 0 Td
(repeat)Tj
2.6532 0 Td
(\(STR\))Tj
2.5738 0 Td
(markers)Tj
3.4583 0 Td
(such)Tj
2.0352 0 Td
(as)Tj
-33.2104 -1.304 Td
(microsatellites)Tj
5.879 0 Td
(informs)Tj
3.3392 0 Td
(on)Tj
1.2642 0 Td
(diversity,)Tj
3.8097 0 Td
(population)Tj
4.5298 0 Td
(structure)Tj
3.77 0 Td
(and)Tj
1.7121 0 Td
(underlying)Tj
4.5411 0 Td
(transmission)Tj
5.2951 0 Td
(pat-)Tj
-34.1402 -1.2982 Td
(terns.)Tj
2.4151 0 Td
(We)Tj
1.593 0 Td
(have)Tj
2.0409 0 Td
(established)Tj
4.5298 0 Td
(vivaxGEN,)Tj
4.4844 0 Td
(an)Tj
1.1905 0 Td
(online)Tj
2.7269 0 Td
(platform)Tj
3.6567 0 Td
(providing)Tj
4.0875 0 Td
(a)Tj
0.652 0 Td
(repository)Tj
4.2349 0 Td
(for)Tj
/F13 1 Tf
1.372 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
-32.9837 -1.2983 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.279 0 Td
(STR)Tj
1.9105 0 Td
(genotyping)Tj
4.6545 0 Td
(data,)Tj
2.109 0 Td
(and)Tj
1.7121 0 Td
(tools)Tj
2.1089 0 Td
(for)Tj
1.3663 0 Td
(standard)Tj
3.6794 0 Td
(population)Tj
4.5297 0 Td
(genetic)Tj
3.0274 0 Td
(analyses.)Tj
3.651 0 Td
(The)Tj
1.7688 0 Td
(plat-)Tj
-32.7966 -1.3039 Td
(form)Tj
2.1826 0 Td
(currently)Tj
3.8324 0 Td
(holds)Tj
2.3584 0 Td
(publicly)Tj
3.3619 0 Td
(available)Tj
3.6113 0 Td
(data)Tj
1.8936 0 Td
(from)Tj
2.1826 0 Td
(5)Tj
0.686 0 Td
(vivax-endemic)Tj
6.0037 0 Td
(countries)Tj
3.8948 0 Td
(that)Tj
1.7518 0 Td
(can)Tj
1.6101 0 Td
(be)Tj
-33.3692 -1.2983 Td
(browsed)Tj
3.5546 0 Td
(on)Tj
1.2642 0 Td
(the)Tj
1.4457 0 Td
(website)Tj
3.1407 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(http://vivaxgen.menzies.edu.a)Tj
12.0472 0 Td
(u)Tj
0 g
(\).)Tj
1.2869 0 Td
(VivaxGEN)Tj
4.5071 0 Td
(will)Tj
1.6384 0 Td
(support)Tj
3.2712 0 Td
(research-)Tj
-32.156 -1.2982 Td
(ers)Tj
1.3549 0 Td
(to)Tj
1.0091 0 Td
(conduct)Tj
3.4299 0 Td
(local)Tj
2.041 0 Td
(STR-based)Tj
/F13 1 Tf
4.473 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9751 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.2734 0 Td
(studies)Tj
2.9367 0 Td
(with)Tj
1.9729 0 Td
(greater)Tj
2.9593 0 Td
(autonomy)Tj
4.2633 0 Td
(and)Tj
1.7064 0 Td
(foster)Tj
2.4322 0 Td
(collabora-)Tj
-31.8272 -1.2983 Td
(tive)Tj
1.6384 0 Td
(studies)Tj
2.948 0 Td
(enabling)Tj
3.6113 0 Td
(regional)Tj
3.4356 0 Td
(overviews)Tj
4.1102 0 Td
(of)Tj
/F13 1 Tf
1.0034 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9808 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.2791 0 Td
(diversity)Tj
3.5943 0 Td
(in)Tj
1.0204 0 Td
(different)Tj
3.6 0 Td
(endemic)Tj
3.617 0 Td
(settings)Tj
-31.8385 -1.3039 Td
(and)Tj
1.7121 0 Td
(across)Tj
2.6418 0 Td
(borders.)Tj
3.4696 0 Td
(The)Tj
1.7632 0 Td
(system)Tj
2.9026 0 Td
(can)Tj
1.6044 0 Td
(be)Tj
1.1395 0 Td
(adapted)Tj
3.3392 0 Td
(for)Tj
1.372 0 Td
(STR-based)Tj
4.4787 0 Td
(analyses)Tj
3.4356 0 Td
(in)Tj
1.0204 0 Td
(other)Tj
2.3188 0 Td
(microor-)Tj
-31.1979 -1.2983 Td
(ganisms)Tj
3.4355 0 Td
(and)Tj
1.7121 0 Td
(the)Tj
1.4514 0 Td
(open)Tj
2.194 0 Td
(access)Tj
2.6078 0 Td
(source)Tj
2.8006 0 Td
(code)Tj
2.075 0 Td
(is)Tj
0.839 0 Td
(provided)Tj
3.7644 0 Td
(to)Tj
1.0148 0 Td
(facilitate)Tj
3.5433 0 Td
(these)Tj
2.2223 0 Td
(developments.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 281.9905 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 264.9826 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(Asia-Pacific)Tj
4.9776 0 Td
(region,)Tj
/F13 1 Tf
3.0274 0 Td
[()4()4()10()6()4()12()12( )12()]TJ
5.1306 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.3074 0 Td
(is)Tj
0.8504 0 Td
(responsible)Tj
4.7508 0 Td
(for)Tj
1.3833 0 Td
(between)Tj
3.532 0 Td
(20)Tj
1.1678 0 Td
(and)Tj
1.7348 0 Td
(280)Tj
1.6441 0 Td
(million)Tj
-33.0857 -1.2982 Td
(malaria)Tj
3.2258 0 Td
(cases)Tj
2.2223 0 Td
(per)Tj
1.5307 0 Td
(year,)Tj
2.1316 0 Td
(inflicting)Tj
3.8381 0 Td
(a)Tj
0.652 0 Td
(significant)Tj
4.388 0 Td
(burden)Tj
3.1294 0 Td
(of)Tj
1.0148 0 Td
(morbidity)Tj
4.2406 0 Td
(and)Tj
1.7292 0 Td
(mortality.)Tj
4.1385 0 Td
(Over)Tj
2.2167 0 Td
(the)Tj
1.474 0 Td
(last)Tj
-35.9317 -1.2983 Td
(decade,)Tj
3.2031 0 Td
(the)Tj
1.4683 0 Td
(prevalence)Tj
4.4901 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()9()11()4(\r)1()10()4()16()-9( )12()]TJ
/F7 1 Tf
4.4787 0 Td
(has)Tj
1.542 0 Td
(declined)Tj
3.6057 0 Td
(in)Tj
1.0375 0 Td
(many)Tj
2.4774 0 Td
(endemic)Tj
3.651 0 Td
(countries)Tj
3.9458 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6577 0 Td
(result)Tj
2.4491 0 Td
(of)Tj
-36.0281 -1.3039 Td
(intensified)Tj
4.439 0 Td
(malaria)Tj
3.2258 0 Td
(control)Tj
3.1237 0 Td
(interventions,)Tj
5.76 0 Td
(but)Tj
1.5534 0 Td
(outside)Tj
3.1351 0 Td
(Africa)Tj
2.6872 0 Td
(this)Tj
1.6724 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1259 0 Td
(associated)Tj
4.252 0 Td
(with)Tj
2.0012 0 Td
(a)Tj
0.652 0 Td
(rise)Tj
-36.1698 -1.2983 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(proportion)Tj
4.6317 0 Td
(of)Tj
/F13 1 Tf
1.0148 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9922 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.3073 0 Td
(cases,)Tj
2.4492 0 Td
(reflecting)Tj
3.9741 0 Td
(the)Tj
1.4684 0 Td
(limited)Tj
3.0727 0 Td
(efficacy)Tj
3.2201 0 Td
(of)Tj
1.0148 0 Td
(interventions)Tj
5.5389 0 Td
(against)Tj
3.0274 0 Td
(this)Tj
-35.2174 -1.2982 Td
(species)Tj
2.9933 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(This)Tj
1.9843 0 Td
(trend)Tj
2.3924 0 Td
(emphasizes)Tj
4.7678 0 Td
(the)Tj
1.4684 0 Td
(need)Tj
2.1429 0 Td
(for)Tj
1.389 0 Td
(innovative)Tj
4.422 0 Td
(new)Tj
1.8766 0 Td
(strategies)Tj
3.9231 0 Td
(to)Tj
1.0261 0 Td
(reduce)Tj
/F13 1 Tf
2.914 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9978 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
-33.9021 -1.3039 Td
(transmission.)Tj
5.5898 0 Td
(A)Tj
0.9014 0 Td
(critical)Tj
2.9537 0 Td
(weakness)Tj
3.9515 0 Td
(of)Tj
1.0148 0 Td
(conventional)Tj
5.4255 0 Td
(malaria)Tj
3.2258 0 Td
(surveillance)Tj
4.9492 0 Td
(is)Tj
0.8448 0 Td
(the)Tj
1.474 0 Td
(lack)Tj
1.8198 0 Td
(of)Tj
1.0148 0 Td
(informa-)Tj
-33.1651 -1.2983 Td
(tion)Tj
1.8311 0 Td
(on)Tj
1.2643 0 Td
(the)Tj
1.4626 0 Td
(genetic)Tj
3.0558 0 Td
(dynamics)Tj
4.0478 0 Td
(of)Tj
1.0035 0 Td
(the)Tj
1.4626 0 Td
(parasite)Tj
3.3165 0 Td
(populationan)Tj
6.4857 0 Td
(important)Tj
4.2746 0 Td
(reflection)Tj
4.0025 0 Td
(of)Tj
1.0091 0 Td
(underlying)Tj
-33.2161 -1.2983 Td
(transmission)Tj
5.3631 0 Td
(potential.)Tj
3.9855 0 Td
(Previous)Tj
3.6906 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.058 0 Td
(demonstrated)Tj
5.7599 0 Td
(the)Tj
1.474 0 Td
(utility)Tj
2.5796 0 Td
(of)Tj
1.0148 0 Td
(genotyping)Tj
4.7111 0 Td
(parasite)Tj
-33.6243 -1.2982 Td
(population)Tj
4.5864 0 Td
(samples)Tj
3.3845 0 Td
(at)Tj
0.9525 0 Td
(highly)Tj
2.7099 0 Td
(polymorphic)Tj
5.3801 0 Td
(short)Tj
2.2847 0 Td
(tandem)Tj
3.2712 0 Td
(repeat)Tj
2.6872 0 Td
(\(STR\))Tj
2.6078 0 Td
(markers)Tj
3.498 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(micro-)Tj
-34.435 -1.304 Td
(satellites)Tj
3.5773 0 Td
(to)Tj
1.0261 0 Td
(inform)Tj
3.0217 0 Td
(on)Tj
/F13 1 Tf
1.2756 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[(\n)-13()15(\n)3()]TJ
/F7 1 Tf
2.3074 0 Td
(diversity,)Tj
3.8721 0 Td
(population)Tj
4.5921 0 Td
(structure)Tj
3.8211 0 Td
(and)Tj
1.7291 0 Td
(underlying)Tj
4.6034 0 Td
(transmission)Tj
-30.818 -1.2982 Td
(patterns)Tj
3.4695 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
3.0728 0 Td
(These)Tj
2.5681 0 Td
(simple)Tj
2.8517 0 Td
(molecular)Tj
4.2179 0 Td
(approaches)Tj
4.7395 0 Td
(complement)Tj
5.2441 0 Td
(the)Tj
1.474 0 Td
(more)Tj
2.3414 0 Td
(traditional)Tj
4.4163 0 Td
(mea-)Tj
-34.3953 -1.2983 Td
(sures)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(transmission)Tj
5.3631 0 Td
(intensity)Tj
3.6907 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(providing)Tj
4.1442 0 Td
(a)Tj
0.6577 0 Td
(surrogate)Tj
3.9741 0 Td
(marker)Tj
3.1408 0 Td
(for)Tj
1.3833 0 Td
(transmission)Tj
5.3631 0 Td
(inten-)Tj
-34.8432 -1.3039 Td
(sity,)Tj
1.8255 0 Td
(informing)Tj
4.3029 0 Td
(on)Tj
1.2756 0 Td
(outbreak)Tj
3.7871 0 Td
(dynamics,)Tj
4.2802 0 Td
(reservoirs)Tj
4.1329 0 Td
(of)Tj
1.0148 0 Td
(infection,)Tj
4.0139 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(spread)Tj
2.8516 0 Td
(of)Tj
1.0148 0 Td
(infection)Tj
-31.7024 -1.2983 Td
(spread)Tj
2.8516 0 Td
(within)Tj
2.8176 0 Td
(and)Tj
1.7291 0 Td
(across)Tj
2.6759 0 Td
(borders)Tj
3.2882 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 183.2882 23.6976 re
W* n
q
183.2315 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 372.1889 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(VivaxGEN)Tj
4.5496 0 Td
(:)Tj
/F6 1 Tf
0.4961 0 Td
(Plasmodi)Tj
4.0394 0 Td
(um)Tj
1.5945 0 Td
(vivax)Tj
/F0 1 Tf
2.459 0 Td
(genotypin)Tj
4.252 0 Td
(g)Tj
0.7654 0 Td
(analysis)Tj
3.763 0 Td
(platform)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
163.5591 34.9228 m
317.7071 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Neglected)Tj
4.6417 0 Td
(Tropical)Tj
3.7135 0 Td
(Disease)Tj
3.5433 0 Td
(s)Tj
0.7158 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8197 0 Td
(1/journal.pn)Tj
5.1237 0 Td
(td.00054)Tj
3.8197 0 Td
(65)Tj
0 g
2.0905 0 Td
(March)Tj
2.9623 0 Td
(31,)Tj
1.5803 0 Td
(2017)Tj
24.3852 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(12)Tj
/F10 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(EDB)Tj
1.8071 0 Td
(is)Tj
0.8362 0 Td
(funded)Tj
2.785 0 Td
(by)Tj
1.1197 0 Td
(the)Tj
1.3678 0 Td
(Wellcome)Tj
3.9047 0 Td
(Trust)Tj
-11.8205 -1.3748 Td
(\(Ref.)Tj
2.0126 0 Td
(100217/Z/12/A)Tj
5.5559 0 Td
(\))Tj
0.5244 0 Td
(and)Tj
1.5874 0 Td
(the)Tj
1.3749 0 Td
(UK)Tj
1.3322 0 Td
(Medical)Tj
3.0969 0 Td
(Research)Tj
-15.4843 -1.3749 Td
(Council)Tj
2.9764 0 Td
(\(Ref.)Tj
2.0126 0 Td
(MR/K00055)Tj
4.4858 0 Td
(1/1\).)Tj
1.9559 0 Td
(TGC)Tj
1.8071 0 Td
(is)Tj
0.8363 0 Td
(funded)Tj
2.7921 0 Td
(by)Tj
-16.8662 -1.3748 Td
(the)Tj
1.3677 0 Td
(UK)Tj
1.3323 0 Td
(Medical)Tj
3.1039 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(Council)Tj
2.9764 0 Td
(\(Grant)Tj
2.5725 0 Td
(no.)Tj
1.3889 0 Td
(MR/)Tj
-16.4339 -1.3748 Td
(K000551/1,)Tj
4.5354 0 Td
(MR/M01360X)Tj
5.2442 0 Td
(/1,)Tj
1.1763 0 Td
(MR/N010)Tj
3.6001 0 Td
(469/1\).The)Tj
-14.556 -1.3748 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6087 0 Td
(in)Tj
0.8929 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.793 0 Td
(collection)Tj
-15.2576 -1.3748 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4362 0 Td
(of)Tj
-17.8229 -1.3748 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F9 1 Tf
-1.3677 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
26 0 obj
<>stream
endstream
endobj
27 0 obj
<>stream
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
BT
10.3394 70.9659 Td
(exist.)Tj
ET
Q
endstream
endobj
32 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 34 0 R/Contents 35 0 R/TrimBox[0 0 612 792]>>
endobj
33 0 obj
<>
endobj
36 0 obj
<>
endobj
37 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Maths_Italic def
/FontType 1 def
/FontBBox {-31 -239 1041 750} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Italic) readonly def
/BaseFontName (TeX_CM_Maths_Italic) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤.vA2*Sr 2@Y0}Rcx,TX|ZP
;o<[1?
T<=qo:-62/]8~i wX?wJ`lLkI@EjYׅq5ڧHtvc6i 0M]YUN;M]ť0]z[{s1uO[6be#9k~d/YpMA.=뤎P\|W#?W$iz81ZL
Ңri^?WP]X A.@
z[
75y6k .U*3}hA\t&HW!Q
=+Г A 5