Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.


Gomes, AR; Ravenhall, M; Benavente, ED; Talman, A; Sutherland, C; Roper, C; Clark, TG; Campino, S; (2017) Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes. Int J Parasitol Drugs Drug Resist, 7 (2). pp. 174-180. ISSN 2211-3207 DOI: 10.1016/j.ijpddr.2017.03.001

[img] Text - Published Version
License:

Download (874Kb)

Abstract

Drug resistance is a recurrent problem in the fight against malaria. Genetic and epidemiological surveillance of antimalarial resistant parasite alleles is crucial to guide drug therapies and clinical management. New antimalarial compounds are currently at various stages of clinical trials and regulatory evaluation. Using ∼2000 Plasmodium falciparum genome sequences, we investigated the genetic diversity of eleven gene-targets of promising antimalarial compounds and assessed their potential efficiency across malaria endemic regions. We determined if the loci are under selection prior to the introduction of new drugs and established a baseline of genetic variance, including potential resistant alleles, for future surveillance programmes.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 28376349
URI: http://researchonline.lshtm.ac.uk/id/eprint/3716501

Statistics


Download activity - last 12 months
Downloads since deposit
26Downloads
46Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item