Quantitative signal detection using spontaneous ADR reporting.

Bate, A; Evans, SJ; (2009) Quantitative signal detection using spontaneous ADR reporting. Pharmacoepidemiology and drug safety, 18 (6). pp. 427-36. ISSN 1053-8569 DOI: https://doi.org/10.1002/pds.1742

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Quantitative methods are increasingly used to analyse spontaneous reports. We describe the core concepts behind the most common methods, the proportional reporting ratio (PRR), reporting odds ratio (ROR), information component (IC) and empirical Bayes geometric mean (EBGM). We discuss the role of Bayesian shrinkage in screening spontaneous reports, the importance of changes over time in screening the properties of the measures. Additionally we discuss three major areas of controversy and ongoing research: stratification, method evaluation and implementation. Finally we give some suggestions as to where emerging research is likely to lead.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 19358225
Web of Science ID: 267349300001
URI: http://researchonline.lshtm.ac.uk/id/eprint/3687


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