Origin and dissemination across Colombian Andes mountain range of Plasmodium falciparum Sulfadoxine-Pyrimethamine resistance.


Corredor, V; Murillo, C; Echeverry, DF; Benavides, J; Pearce, RJ; Roper, C; Guerra, AP; Osorio, L; (2010) Origin and dissemination across Colombian Andes mountain range of Plasmodium falciparum Sulfadoxine-Pyrimethamine resistance. Antimicrobial agents and chemotherapy, 54 (8). pp. 3121-5. ISSN 0066-4804 DOI: 10.1128/AAC.00036-10

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Abstract

: The therapeutic efficacy of sulfadoxine-pyrimethamine (SP) in treating uncomplicated Plasmodium falciparum malaria is unevenly distributed in Colombia. The Andes mountain range separates regions in the west where malaria is endemic from those in the east and constitutes a barrier against gene flow and the dispersal of parasite populations. The distribution of dhfr and dhps genotypes of 146 P. falciparum samples from the eastern Amazon and Orinoco basins and Northwest and Southwest Pacific regions of Colombia was consistent with the documented levels of therapeutic efficacy of SP. The diversity of four dhfr- and dhps-linked microsatellites indicated that double- and triple-mutant alleles for both resistance loci have a single origin. Likewise, multilocus association genotypes, including two unlinked microsatellite loci, suggested that genetic exchanges between the eastern Orinoco and Northwest Pacific populations has taken place across the Andes, most probably via migration of infected people.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 20498318
Web of Science ID: 279963300007
URI: http://researchonline.lshtm.ac.uk/id/eprint/3647

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