Hyporesponsiveness to re-challenge dose following pneumococcal polysaccharide vaccine at 12 months of age, a randomized controlled trial


Russell, FM; Carapetis, JR; Balloch, A; Licciardi, PV; Jenney, AWJ; Tikoduadua, L; Waqatakirewa, L; Pryor, J; Nelson, J; Byrnes, GB; Cheung, YB; Tang, MLK; Mulholland, EK; (2010) Hyporesponsiveness to re-challenge dose following pneumococcal polysaccharide vaccine at 12 months of age, a randomized controlled trial. Vaccine, 28 (19). pp. 3341-3349. ISSN 0264-410X DOI: 10.1016/j.vaccine.2010.02.087

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Abstract

Background: To evaluate the immunological impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPS) at 12 months, for children who have received zero to three infant doses of seven-valent pneumococcal conjugate vaccine (PCV), on responses to a subsequent exposure to a small close of 23vPPS (mPPS). Methods Five hundred and fifty-two Fijian infants were stratified by ethnicity and randomized into eight groups to receive zero, one, two, or three PCV doses at 14 weeks, six and 14 weeks, or six, ten, and 14 weeks Within each group, half received 23vPPS at 12 months and all received mPPS at 17 months. Sera were taken prior and one month post-mPPS. Findings. By 17 months, geometric mean antibody concentrations (GMC) to all 23 serotypes in 23vPPS were significantly higher in children who had received 23vPPS at 12 months compared to those who had not Post-mPPS, children who had not received the 12 month 23vPPS had a significantly higher GMC for all PCV serotypes compared with those who had (each p < 0 02). For the non-PCV serotypes, children who had not received the 12 month 23vPPS had significantly higher GMC for six of 16 non-PCV serotypes (7F, 9N, 12F, 19A, 22F, 33F) than those who did (each p < 0 02) After adjusting for the pre-mPPS level, exposure to 23vPPS was associated with a lower response to mPPS for all serotypes (each p < 0 001) Interpretation. Despite higher antibody concentrations at 17 months in children who had received 23vPPS at 12 months, the response to a re-challenge was poor for all 23 serotypes compared to children who had not received the 12 month 23vPPS. (C) 2010 Elsevier Ltd. All rights reserved

Item Type: Article
Keywords: Pneumococcal vaccines, Immunogenicity, Hyporesponsiveness, acute otitis-media, intact streptococcus-pneumoniae, independent, immune-responses, cd4(+) t-cells, conjugate vaccine, capsular, polysaccharide, antibody-responses, differential regulation, immunological memory, african children
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Vaccine Centre
PubMed ID: 20206670
Web of Science ID: 277677000012
URI: http://researchonline.lshtm.ac.uk/id/eprint/3617

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