Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population.


Costa, RD; Figueiredo, CA; Barreto, ML; Alcantara-Neves, NM; Rodrigues, LC; Cruz, AA; Vergara, C; Rafaels, N; Foster, C; Potee, J; Campbell, M; Mathias, RA; Barnes, KC; (2017) Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population. Annals of allergy, asthma & immunology , 118 (4). 483-488.e1. ISSN 1081-1206 DOI: 10.1016/j.anai.2017.01.028

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Abstract

: Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation. The role of TGF- β 1 single-nucleotide polymorphisms (SNPs) in allergic disease remains inconclusive.<br/> : To evaluate the effects of genetic variations in the TGF-β1 on allergy and helminths infections in children.<br/> : We tested for association among 4 TGF-β1 SNPs and allergic asthma, specific IgE, skin prick test result, and IL-10 production in 1,335 Brazilians. In addition, we analyzed the association with markers of helminth infection (parasite burden, anti-Ascaris IgE, and worm specific IgG4). The polymorphisms were genotyped using Taq Man probes.<br/> : We found an association between rs1800470 (C allele) and atopic wheezing (odds ratio [OR], 0.60; 95% confidence interval [CI], 0.37-0.95) and markers of allergy (OR, 0.41; 95% CI, 0.22-0.79). In contrast, a positive association was observed between the haplotype ACCA and Trichuris trichiura infection (OR, 1.85; P = .003) and Ascaris lumbricoides infection (OR, 2.01; P < .001). This haplotype was also associated with increased IL-10 production (β = 50.7; P < .001).<br/> : Individuals with TGF-β1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy. These studies suggest that immune modulation of allergic disease results not only from environmental factors but also from genetic susceptibility and IL-10 production.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 28284979
Web of Science ID: 398936900017
URI: http://researchonline.lshtm.ac.uk/id/eprint/3616345

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