New insights into an X-traordinary viral protein.


Schaller, T; Bauby, H; Hue, S; Malim, MH; Goujon, C; (2014) New insights into an X-traordinary viral protein. Front Microbiol, 5. p. 126. ISSN 1664-302X DOI: https://doi.org/10.3389/fmicb.2014.00126

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Abstract

Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 24782834
Web of Science ID: 333888500001
URI: http://researchonline.lshtm.ac.uk/id/eprint/3548917

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