Comparison of Six Commonly Used QT Correction Models and Their Parameter Estimation Methods.


Wang, D; Taubel, J; Arezina, R; (2012) Comparison of Six Commonly Used QT Correction Models and Their Parameter Estimation Methods. Journal of biopharmaceutical statistics, 22 (6). pp. 1148-61. ISSN 1054-3406 DOI: https://doi.org/10.1080/10543406.2011.577261

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Abstract

: This paper compares six commonly used QT correction models and three available parameter estimation methods using five indices for QTc evaluation based on real and simulated electrocardiograph (ECG) datasets. The results show that the golden section approach always finds the correction factor making QTc interval uncorrelated to heart rate for all six formulas. However, the correction formulas derived from mixed model sometimes fail to make QTc interval invariant of heart rate. The performance of an individual least-square regression method lies between the golden section iteration approach and the mixed model in terms of QTc-RR relationship.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 23075014
Web of Science ID: 310133900005
URI: http://researchonline.lshtm.ac.uk/id/eprint/354888

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