How informative is a negative finding in a small pharmacogenetic study?


Bacanu, SA; Whittaker, JC; Nelson, MR; (2012) How informative is a negative finding in a small pharmacogenetic study? The pharmacogenomics journal, 12 (2). pp. 93-5. ISSN 1470-269X DOI: https://doi.org/10.1038/tpj.2011.58

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Abstract

: Many pharmacogenetic studies fail to yield any statistically significant associations. Such negative findings may be due to the absence of, or inadequate statistical power to test for, an effect at the genetic variants tested. In many instances, sample sizes are small, making it unclear how to interpret the absence of statistically significant findings. We demonstrate that the amount of information that can be drawn from a negative study is improved by incorporating statistical power and the added context of well-validated pharmacogenetic effects into the interpretation process. This approach permits clearer inferences to be made about the possible range of genetic effects that may be present in, or are likely absent from, small drug studies.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 22158332
Web of Science ID: 302133700001
URI: http://researchonline.lshtm.ac.uk/id/eprint/354879

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