Performance of the BioPlex 2200 Multiplexing Immunoassay Platform for the Detection of Herpes Simplex Virus Type 2 Specific Antibodies in African Settings


Legoff, J; Gresenguet, G; Gody, C; Longo, JD; Khonde, N; Weiss, HA; Mayaud, P; Belec, L; Grp, AS; (2011) Performance of the BioPlex 2200 Multiplexing Immunoassay Platform for the Detection of Herpes Simplex Virus Type 2 Specific Antibodies in African Settings. Clinical and vaccine immunology, 18 (7). pp. 1191-1193. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.05003-11

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Abstract

The BioPlex platform was evaluated for the detection of herpes simplex virus 2 (HSV-2) antibodies in sub-Saharan Africa individuals in comparison to clinicovirological standards and compared to HerpeSelect. The sensitivities and specificities were, respectively, 88.9% and 93.5% for BioPlex and 89.9% and 92.7% for HerpeSelect. The agreement between both assays was 95.7%.

Item Type: Article
Keywords: linked immunosorbent assays, placebo-controlled trial, plasma hiv-1, rna, enzyme-immunoassay, genital herpes, women, focus, hsv-2, acyclovir, impact
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Tropical Epidemiology Group
PubMed ID: 21562116
Web of Science ID: 292378200022
URI: http://researchonline.lshtm.ac.uk/id/eprint/354

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