Cost-effectiveness analysis of a hypothetical hepatitis C vaccine compared to antiviral therapy


Massad, E; Coutinho, FAB; Chaib, E; Burattini, MN; (2009) Cost-effectiveness analysis of a hypothetical hepatitis C vaccine compared to antiviral therapy. Epidemiology and infection, 137 (2). pp. 241-249. ISSN 0950-2688 DOI: 10.1017/S0950268808000873

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Abstract

We propose a mathematical model to simulate the dynamics of hepatitis C virus (HCV) infection in the state of Sao Paulo, Brazil. We assumed that a hypothetical vaccine, which cost was taken to be the initial cost of the vaccine against hepatitis B exists and it is introduced in the model. We computed its cost-effectiveness compared with the anti-HCV therapy. The calculated basic reproduction number was 1.20. The model predicts that without intervention a steady state exists with an HCV prevalence of 3%, in agreement with the Current epidemiological data. Starting from this steady state three interventions were simulated: indiscriminate vaccination, selective vaccination and anti-HCV therapy. Selective vaccination proved to be the strategy with the best cost-effectiveness ratio, followed by indiscriminate vaccination and anti-HCV therapy.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 18631422
Web of Science ID: 262774800015
URI: http://researchonline.lshtm.ac.uk/id/eprint/3515797

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