The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches.


Bednarska, NG; Wren, BW; Willcocks, SJ; (2017) The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches. Drug discovery today. ISSN 1359-6446 DOI: 10.1016/j.drudis.2017.02.001

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Abstract

: Glycosylation is one of the most prevalent post-translational modifications of a protein, with a defining impact on its structure and function. Many of the proteins involved in the innate or adaptive immune response, including cytokines, chemokines, and antimicrobial peptides (AMPs), are glycosylated, contributing to their myriad activities. The current availability of synthetic coupling and glycoengineering technology makes it possible to customise the most beneficial glycan modifications for improved AMP stability, microbicidal potency, pathogen specificity, tissue or cell targeting, and immunomodulation.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 28212948
URI: http://researchonline.lshtm.ac.uk/id/eprint/3515717

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