The perils of PCR: can we accurately 'correct' antimalarial trials?

Juliano, JJ; Gadalla, N; Sutherland, CJ; Meshnick, SR; (2010) The perils of PCR: can we accurately 'correct' antimalarial trials? Trends in parasitology, 26 (3). pp. 119-24. ISSN 1471-4922 DOI:

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During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates. The epidemiological, biological and technical limitations of PCR correction and how this can lead to misclassification in drug trial outcomes are underappreciated. This article considers these limitations and proposes a framework for reporting, interpreting and improving PCR correction of antimalarial trials.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 20083436
Web of Science ID: 275804700005


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