Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data.
Sheppard, AE; Vaughan, A; Jones, N; Turner, P; Turner, C; Efstratiou, A; Patel, D; Modernising Medical Microbiology Informatics Group; Walker, AS; Berkley, JA; Crook, DW; Seale, AC; (2016) Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data. Journal of clinical microbiology, 54 (5). pp. 1388-90. ISSN 0095-1137 DOI: 10.1128/JCM.03142-15
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Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.
|Faculty and Department:||Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology|
|Research Centre:||Antimicrobial Resistance Centre (AMR)|
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