Ocular surface squamous neoplasia as the first apparent manifestation of HIV infection in Malawi.


Spitzer, MS; Batumba, NH; Chirambo, T; Bartz-Schmidt, KU; Kayange, P; Kalua, K; Szurman, P; (2008) Ocular surface squamous neoplasia as the first apparent manifestation of HIV infection in Malawi. Clinical & experimental ophthalmology, 36 (5). pp. 422-5. ISSN 1442-6404 DOI: https://doi.org/10.1111/j.1442-9071.2008.01794.x

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Abstract

PURPOSE: To evaluate the prevalence of undiagnosed and asymptomatic HIV infection in patients with ocular surface squamous neoplasia (OSSN) in an urban patient population in Malawi. METHODS: A consecutive series of patients presenting with OSSN was evaluated in an African academic centre. A detailed history and physical examination in 53 consecutive patients with conjunctival squamous cell carcinoma and conjunctival intraepithelial neoplasia were performed. Thirty eight (72%) patients agreed to undergo serological HIV testing. RESULTS: Seventy-nine per cent (30 of 38) patients were HIV positive. None of the patients had previous HIV testing or was aware of having symptoms of HIV. Seventy per cent (n = 21) of the HIV-positive patients had no other symptoms suggestive of HIV infection or any other disease. Patients were far more likely to refuse HIV testing if they were married and male. CONCLUSIONS: The conjunctival tumour may be the primary and only apparent manifestation of HIV in patients presenting with OSSN in Sub-Saharan Africa.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 18939345
Web of Science ID: 258727600006
URI: http://researchonline.lshtm.ac.uk/id/eprint/3456

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