Major depressive disorder and suicidality in early HIV infection and its association with risk factors and negative outcomes as seen in semi-urban and rural Uganda.


Kinyanda, E; Nakasujja, N; Levin, J; Birabwa, H; Mpango, R; Grosskurth, H; Seedat, S; Patel, V; (2017) Major depressive disorder and suicidality in early HIV infection and its association with risk factors and negative outcomes as seen in semi-urban and rural Uganda. Journal of affective disorders, 212. pp. 117-127. ISSN 0165-0327 DOI: https://doi.org/10.1016/j.jad.2017.01.033

This is the latest version of this item. Earlier version may have full text manuscript

[img]
Preview
Text - Accepted Version
License:

Download (321kB) | Preview
[img]
Preview
Text - Supplemental Material
License:

Download (248kB) | Preview
[img]
Preview
Text - Supplemental Material
License:

Download (262kB) | Preview
[img]
Preview
Text - Supplemental Material
License:

Download (233kB) | Preview
[img]
Preview
Text - Supplemental Material
License:

Download (232kB) | Preview
[img]
Preview
Text - Supplemental Material
License:

Download (235kB) | Preview
[img]
Preview
Text - Supplemental Material
License:

Download (184kB) | Preview

Abstract

: There is a paucity of research into the psychiatric problems associated with early stage HIV clinical disease in sub-Saharan Africa.<br/> : A cross sectional study was undertaken among 899 adult ART naïve persons in early stage HIV clinical disease (participants with CD4≥250 and who were at WHO clinical Stage I or II) attending a semi-urban and a rural clinic in Uganda.<br/> : The prevalence of major depressive disorder in this study was 14.0% [95% CI 11.7-6.3%] while that of 'moderate to high risk for suicidality' was 2.8% [95% CI 1.7%; 3.9%]. Multivariable analyses found that factors in the socio-demographic, vulnerability/protective and stress (only for major depressive disorder) domains were significantly associated with both major depressive disorder and 'moderate to high risk for suicidality'. Major depressive disorder but not 'moderate to high risk for suicidality' was significantly associated with impaired psychosocial functioning, greater utilisation of health services and non-adherence to septrin/dasone. Neither major depressive disorder nor 'moderate to high risk for suicidality' was associated with CD4 counts, risky sexual behaviour nor with non-utilisation of condoms.<br/> : The bidirectional nature of some of the relationships between the investigated psychiatric problems, risk factors and outcomes in this cross sectional study makes it difficult to elucidate the actual direction of causality.<br/> : Early stage HIV clinical disease is associated with considerable major depressive disorder and 'moderate to high risk for suicidality'. Therefore there is a need to integrate mental health into HIV interventions that target early stage HIV disease.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
PubMed ID: 28160684
Web of Science ID: 398008600017
URI: http://researchonline.lshtm.ac.uk/id/eprint/3449637

Available Versions of this Item

Statistics


Download activity - last 12 months
Downloads since deposit
77Downloads
53Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item