Pfk13-independent treatment failure in four imported cases of Plasmodium falciparum malaria given artemether-lumefantrine in the UK.


Sutherland, CJ; Lansdell, P; Sanders, M; Muwanguzi, J; van Schalkwyk, DA; Kaur, H; Nolder, D; Tucker, J; Bennett, HM; Otto, TD; Berriman, M; Patel, TA; Lynn, R; Gkrania-Klotsas, E; Chiodini, PL; (2017) Pfk13-independent treatment failure in four imported cases of Plasmodium falciparum malaria given artemether-lumefantrine in the UK. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: 10.1128/AAC.02382-16

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Abstract

We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015-16. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitaemia within 6 weeks of treatment with no intervening travel to malarious countries. Parasite isolates, all of African origin, harboured variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Malaria Centre
Antimicrobial Resistance Centre (AMR)
PubMed ID: 28137810
URI: http://researchonline.lshtm.ac.uk/id/eprint/3429868

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