Early impact of rotavirus vaccination in a large paediatric hospital in the UK.

Hungerford, D; Read, JM; Cooke, RP; Vivancos, R; Iturriza-Gómara, M; Allen, DJ; French, N; Cunliffe, N; (2015) Early impact of rotavirus vaccination in a large paediatric hospital in the UK. Technical Report. Elsevier. DOI: https://doi.org/10.1016/j.jhin.2015.12.010

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The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.

Item Type: Monograph
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 26876744
Web of Science ID: 376685600002
URI: http://researchonline.lshtm.ac.uk/id/eprint/3417005


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