Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization


Licciardi, PV; Balloch, A; Russell, FM; Mulholland, EK; Tang, MLK; (2010) Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization. Vaccine, 28 (22). pp. 3793-3800. ISSN 0264-410X DOI: 10.1016/j.vaccine.2010.03.033

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Abstract

Cross-reactivity within the pneumococcal immune response was examined in this study. Significant cross-reactivity between serotypes 9V, 15B and 19A was identified in infant post-immunization serum that could not be effectively titrated during specific IgG measurements. Pre-absorption using serotype 9V inhibited this cross-reactivity and normalized titratability in the WHO ELISA for serotypes 15B and 19A. However, this did not affect functional avid IgG and was associated with fewer pneumococcal conjugate vaccine (PCV) doses, suggesting that cross-reactive antibodies were of low avidity. The results in this study have important implications for assessment of vaccine immunogenicity. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Pneumococcal, Cross-reactive, Antibody, LINKED-IMMUNOSORBENT-ASSAY, MEDIA VACCINE TRIAL, CAPSULAR, POLYSACCHARIDES, STREPTOCOCCUS-PNEUMONIAE, CONJUGATE VACCINES, MONOCLONAL-ANTIBODIES, FUNCTIONAL ANTIBODIES, C-POLYSACCHARIDE, IMMUNITY, QUANTITATION
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 20362199
Web of Science ID: 278877900008
URI: http://researchonline.lshtm.ac.uk/id/eprint/3368

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