Type I Interferon in Malaria: A Balancing Act.


Mooney, JP; Wassmer, SC; Hafalla, JC; (2017) Type I Interferon in Malaria: A Balancing Act. Trends in parasitology. ISSN 1471-4922 DOI: 10.1016/j.pt.2016.12.010

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Abstract

: Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical protection to malaria. New studies recently highlighted a central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of proinflammatory responses, expansion of type 1 regulatory (Tr1) cells, and restriction of humoral immunity during malaria blood stage infection. Plasmacytoid dendritic cells (pDCs) were identified as the major source of IFN-Is. Here, we integrate the findings and provide a model for the mechanisms involved.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 28094200
Web of Science ID: 399626400003
URI: http://researchonline.lshtm.ac.uk/id/eprint/3366911

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