Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda.


Tumwebaze, P; Tukwasibwe, S; Taylor, A; Conrad, M; Ruhamyankaka, E; Asua, V; Walakira, A; Nankabirwa, J; Yeka, A; Staedke, SG; Greenhouse, B; Nsobya, SL; Kamya, MR; Dorsey, G; Rosenthal, PJ; (2016) Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda. The Journal of infectious diseases, 215 (4). pp. 631-635. ISSN 0022-1899 DOI: 10.1093/infdis/jiw614

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Abstract

: We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 28039354
Web of Science ID: 398422100019
URI: http://researchonline.lshtm.ac.uk/id/eprint/3363664

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