Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension. Data from the Hypertension in the Very Elderly Trial (HYVET)


Peters, R; Pinto, E; Beckett, N; Swift, C; Potter, J; McCormack, T; Nunes, M; Grimley-Evans, J; Fletcher, A; Bulpitt, C; (2010) Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension. Data from the Hypertension in the Very Elderly Trial (HYVET). Age and ageing, 39 (4). pp. 439-445. ISSN 0002-0729 DOI: https://doi.org/10.1093/ageing/afq042

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Abstract

Background: depression is common in elderly people and may be associated with increased cardiovascular risk and incident dementia. Method: participants in the Hypertension in the Very Elderly Trial (HYVET) completed a depression screening instrument, the Geriatric Depression Score (GDS), at baseline and annually. We examined the association of GDS score with incident stroke, mortality and dementia using Cox proportional hazards models (hazard ratios, HR and 95% confidence intervals, CI) adjusted for treatment group and other potential confounders. Results: 2,656 HYVET participants completed the GDS. The mean follow-up was 2.1 years. A GDS score >= 6 was associated with increased risks of all-cause (HR 1.8, 95% CI 1.4-2.3) and cardiovascular mortality (HR 2.10, 95% CI 1.5-3.0), all stroke (HR 1.8, 95% CI 1.2-2.8) and all cardiovascular events (HR 1.6, 95% CI 1.2-2.1). Risk of incident dementia also tended to be increased (HR 1.28, 95% CI 0.95-1.73). Each additional GDS point at baseline also gave rise to a significantly increased risk of fatal and non-fatal cardiovascular events, all-cause mortality and dementia. Conclusion: there was a strong association between baseline depression scores and later fatal and non-fatal cardiovascular endpoints over a mean follow-up of 2 years in a hypertensive very elderly group. The mechanism of this association warrants further study.

Item Type: Article
Keywords: cardiovascular diseases, aged, depression, hypertension, mortality, GOSPEL OAK PROJECT, SHORT VERSIONS, HEART-DISEASE, SCALE GDS-15, OLDER-PEOPLE, SYMPTOMS, RISK, LIFE, COMMUNITY, HEALTH
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: The International Centre for Evidence in Disability
PubMed ID: 20497949
Web of Science ID: 278968300007
URI: http://researchonline.lshtm.ac.uk/id/eprint/3362

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