Serological Evidence of Discrete Spatial Clusters of Plasmodium falciparum Parasites.


Bejon, P; Turner, L; Lavstsen, T; Cham, G; Olotu, A; Drakeley, CJ; Lievens, M; Vekemans, J; Savarese, B; Lusingu, J; von Seidlein, L; Bull, PC; Marsh, K; Theander, TG; (2011) Serological Evidence of Discrete Spatial Clusters of Plasmodium falciparum Parasites. PLoS One, 6 (6). e21711. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0021711

[img]
Preview
Text - Published Version
License:

Download (720kB) | Preview

Abstract

Malaria transmission may be considered to be homogenous with well-mixed parasite populations (as in the classic Ross/Macdonald models). Marked fine-scale heterogeneity of transmission has been observed in the field (i.e., over a few kilometres), but there are relatively few data on the degree of mixing. Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-populations.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 21747921
Web of Science ID: 292290100059
URI: http://researchonline.lshtm.ac.uk/id/eprint/336

Statistics


Download activity - last 12 months
Downloads since deposit
195Downloads
296Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item