Surveillance for early silicosis in high altitude miners using pulse oximetry

Donroe, JA; Maurtua-Neumann, PJ; Gilman, RH; Acosta, AT; Cain, G; Parker, JE; Carhuaricra, JC; Padilla, JJ; Mendoza, D; Zimic, M; Moore, DA; (2008) Surveillance for early silicosis in high altitude miners using pulse oximetry. International journal of occupational and environmental health, 14 (3). pp. 187-92. ISSN 1077-3525 DOI:

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Two cross-sectional studies in a high altitude region of Peru evaluated the role of pulse oximetry for detection of silicosis in high-altitude miners. In study one, exercise pulse oximetry and chest radiographs were used to evaluate 343 silica-exposed miners and 141 unexposed subjects for evidence of silicosis. Study 2 investigated the association between exercise oxygen saturation and silicosis in 32 non-silicotic and 65 silicotic miners. In study one, age (Odds Ratio [OR] 1.10, 95% Cofidence Interval (CI) 1.07-1.12) and resting oxygen saturation (OR 0.95, 95%CI 0.90-0.99) were associated with silicosis. In study two, years of mining employment (OR 1.14, 95%CI 1.05-1.23) and exercise oxygen saturation at 30% maximum heart rate (OR 0.86, 95%CI 0.75-0.99) were associated with silicosis. Hypoxemia at rest and with exercise is associated with silicosis in high altitude miners. Pulse oximetry should be further investigated as a screening tool for silicosis at high altitudes.

Item Type: Article
Keywords: Adult, *Altitude, Confidence Intervals, Cross-Sectional Studies, Humans, *Mining, Occupational Exposure, *Oximetry/instrumentation, Peru, Questionnaires, Silicosis/*diagnosis, Adult, Altitude, Confidence Intervals, Cross-Sectional Studies, Humans, Mining, Occupational Exposure, Oximetry, instrumentation, Peru, Questionnaires, Silicosis, diagnosis
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 18686718
Web of Science ID: 257975300004


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