Birth prevalence of Congenital Talipes Equinovarus in Low and Middle Income Countries: A Systematic Review and Meta-analysis.


Smythe, T; Kuper, H; Macleod, D; Foster, A; Lavy, C; (2016) Birth prevalence of Congenital Talipes Equinovarus in Low and Middle Income Countries: A Systematic Review and Meta-analysis. Tropical medicine & international health . ISSN 1360-2276 DOI: 10.1111/tmi.12833

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Abstract

Congenital talipes equinovarus (CTEV), or clubfoot, is a structural malformation that develops early in gestation. Birth prevalence of clubfoot is reported to vary both between and within low and middle-income countries (LMICs) and this information is needed in order to plan treatment services. This systematic review aims to understand the birth prevalence of clubfoot in LMIC settings. Six databases were searched for studies that reported birth prevalence of clubfoot in LMICs. Results were screened and assessed for eligibility using pre-defined criteria. Data on birth prevalence were extracted and weighted pooled estimates were calculated for different regions. Wilcoxon rank-sum test was used to examine changes in birth prevalence over time. Included studies were appraised for their methodological quality, and a narrative synthesis of findings was conducted. 48 studies provided data from 13,962,989 children in 20 countries over 55 years (1960 - 2015). The pooled estimate for clubfoot birth prevalence in LMICs within the Africa region is 1.11 (0.96, 1.26); in the Americas 1.74 (1.69,1.80); in South East Asia (excluding India) 1.21 (0.73, 1.68); in India 1.19 (0.96, 1.42); in Turkey (Europe Region) 2.03 (1.54, 2.53); in Eastern Mediterranean region 1.19 (0.98, 1.40); in West Pacific (excludes China) 0.94 (0.64, 1.24) and in China 0.51 (0.50, 0.53). Birth prevalence of clubfoot varies between 0.51 and 2.03/1,000 live births in LMICs. A standardised approach to the study of the epidemiology of clubfoot is required to better understand the variations of clubfoot birth prevalence and identify possible risk factors. This article is protected by copyright. All rights reserved.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 28000394
Web of Science ID: 395083700003
URI: http://researchonline.lshtm.ac.uk/id/eprint/3302660

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