The pathogenesis of dengue.


Whitehorn, J; Simmons, CP; (2011) The pathogenesis of dengue. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2011.07.022

[img]
Preview
Text - Accepted Version
License: Copyright the author(s)

Download (304kB) | Preview

Abstract

Dengue is an important cause of childhood and adult morbidity in Asian and Latin American countries and its geographic footprint is growing. The clinical manifestations of dengue are the expression of a constellation of host and viral factors, some acquired, others intrinsic to the individual. The virulence of the virus plus the flavivirus infection history, age, gender and genotype of the host all appear to help shape the severity of infection. Similarly, the characteristics of the innate and acquired host immune response subsequent to infection are also likely determinants of outcome. This review summarises recent developments in the understanding of dengue pathogenesis and their relevance to dengue vaccine development.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 21781999
Web of Science ID: 295662500002
URI: http://researchonline.lshtm.ac.uk/id/eprint/330

Statistics


Download activity - last 12 months
Downloads since deposit
827Downloads
420Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item