Seropositivity to anti-phenolic glycolipid-I in leprosy cases, contacts and no known contacts of leprosy in an endemic and a non-endemic area in northeast Brazil


Frota, CC; Freitas, MVC; Foss, NT; Lima, LNC; Rodrigues, LC; Barreto, ML; Kerr, LRS; (2010) Seropositivity to anti-phenolic glycolipid-I in leprosy cases, contacts and no known contacts of leprosy in an endemic and a non-endemic area in northeast Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104 (7). pp. 490-495. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2010.03.006

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Abstract

The seroprevalence rates of IgM anti-phenolic glycolipid-I (PGL-I) antibodies in four study groups with differing exposure to Mycobacterium leprae in Ceara. Brazil were investigated between March 2005 and August 2006. The first three groups in a high prevalence area included 144 cases of leprosy, their 380 contacts and 317 participants with no known leprosy contact. The fourth group in a low prevalence area consisted of 87 participants with no known leprosy contact living in an area in which no cases of leprosy had been reported in the previous 6 months. Seropositivity and levels of IgM antibodies to PGL-I were investigated using ELISA. The seropositivity levels of anti-PGL-I among the different clinical forms of leprosy cases were 61% for lepromatous, 25% for tuberculoid and 27% indeterminate. The levels of anti-PGL-I antibodies in the endemic area differentiated leprosy cases from non-cases. However, the seropositivity was similar among contact cases (15.8%) and no known leprosy contact cases from high (15.1%) and low (13.8%) prevalence areas. The seropositivity of both contacts and no known contacts was much higher than previously reported among no known contacts in other endemic areas. The study indicates that anti-PGL-I antibodies are not useful as immunological markers of household leprosy contacts and no known leprosy contacts in endemic areas. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Leprosy, Mycobacterium leprae, Seroprevalence, Immunologic marker, Phenolic glycolipid-I, Brazil, MYCOBACTERIUM-LEPRAE, HOUSEHOLD CONTACTS, RISK-FACTORS, SOUTH-INDIA, EPIDEMIOLOGY, POPULATION, SPECIFICITY, MALAWI, STATE, TESTS
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Neglected Tropical Diseases Network
PubMed ID: 20447668
Web of Science ID: 279427100007
URI: http://researchonline.lshtm.ac.uk/id/eprint/3274

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