Methodology and measurement of the effectiveness of Haemophilus influenzae type b vaccine: Systematic review.


O'Loughlin, RE; Edmond, K; Mangtani, P; Cohen, AL; Shetty, S; Hajjeh, R; Mulholland, K; (2010) Methodology and measurement of the effectiveness of Haemophilus influenzae type b vaccine: Systematic review. Vaccine, 28 (38). pp. 6128-36. ISSN 0264-410X DOI: 10.1016/j.vaccine.2010.06.107

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Abstract

: The use of the highly effective Haemophilus influenzae type b (Hib) conjugate vaccine has increased globally. We review the benefits and limitations of studies measuring Hib vaccine effectiveness (VE). We critically examine the case-control approach by assessing the similarities and differences in methodology and findings and discuss the need for future Hib VE studies. In the absence of good surveillance data, vaccine effectiveness studies can play an important role, particularly with the increasing use of pneumococcal vaccine that has not been well tested under field conditions in less developed countries. However, the effectiveness of Hib vaccine has been well documented so the need for future VE Hib studies is minimal.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Vaccine Centre
PubMed ID: 20655402
Web of Science ID: 282150700003
URI: http://researchonline.lshtm.ac.uk/id/eprint/3250

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