Episodic therapy for genital herpes in sub-saharan Africa: a pooled analysis from three randomized controlled trials.


Weiss, HA; Paz Bailey, G; Phiri, S; Gresenguet, G; Legoff, J; Pepin, J; Lewis, DA; Belec, L; Hoffman, IF; Miller, WC; Mayaud, P; (2011) Episodic therapy for genital herpes in sub-saharan Africa: a pooled analysis from three randomized controlled trials. PLoS One, 6 (7). e22601. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0022601

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Abstract

A randomized controlled trial in South Africa found a beneficial effect of acyclovir on genital ulcer healing, but no effect was seen in trials in Ghana, Central African Republic and Malawi. The aim of this paper is to assess whether the variation in impact of acyclovir on ulcer healing in these trials can be explained by differences in the characteristics of the study populations.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Tropical Epidemiology Group
PubMed ID: 21799914
Web of Science ID: 293172900055
URI: http://researchonline.lshtm.ac.uk/id/eprint/325

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