Stability of Dihydroartemisinin-Piperaquine Tablet Halves during Prolonged Storage under Tropical Conditions.


Hodel, EM; Kaur, H; Terlouw, DJ; (2016) Stability of Dihydroartemisinin-Piperaquine Tablet Halves during Prolonged Storage under Tropical Conditions. The American journal of tropical medicine and hygiene. ISSN 0002-9637 DOI: 10.4269/ajtmh.16-0759

[img]
Preview
Text - Published Version
License:

Download (4Mb) | Preview

Abstract

Dihydroartemisinin-piperaquine (DP) is recommended for the treatment of uncomplicated malaria, used in efforts to contain artemisinin resistance, and increasingly considered for mass drug administration. Because of the narrow therapeutic dose range and available tablet strengths, the manufacturers and World Health Organization recommended regimens involve breaking tablets into halves to accurately dose children according to body weight. Use of tablet fractions in programmatic settings under tropical conditions requires a highly stable product; however, the stability of DP tablet fractions is unknown. We aged full and half DP (Eurartesim(®)) tablets in a stability chamber at 30°C and 70% humidity level. The active pharmaceutical ingredients dihydroartemisinin and piperaquine remained at ≥ 95% over the 3 months' period of ageing in light and darkness. These findings are reassuring for DP, but highlight the need to assess drug stability under real-life settings during the drug development process, particularly for key drugs of global disease control programs.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 27895269
URI: http://researchonline.lshtm.ac.uk/id/eprint/3141165

Statistics


Download activity - last 12 months
Downloads since deposit
9Downloads
24Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item