Ebola Virus Disease in Children, Sierra Leone, 2014-2015.

Fitzgerald, F; Naveed, A; Wing, K; Gbessay, M; Ross, JC; Checchi, F; Youkee, D; Jalloh, MB; Baion, D; Mustapha, A; Jah, H; Lako, S; Oza, S; Boufkhed, S; Feury, R; Bielicki, JA; Gibb, DM; Klein, N; Sahr, F; Yeung, S; (2016) Ebola Virus Disease in Children, Sierra Leone, 2014-2015. Emerging infectious diseases, 22 (10). pp. 1769-77. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid2210.160579

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Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014-2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus-positive children 2 days-12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Public Health and Policy > Dept of Global Health and Development
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: EHR Research Group
PubMed ID: 27649367
Web of Science ID: 384387400010
URI: http://researchonline.lshtm.ac.uk/id/eprint/3141160


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