Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung


Redford, PS; Boonstra, A; Read, S; Pitt, J; Graham, C; Stavropoulos, E; Bancroft, GJ; O'Garra, A; (2010) Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. European journal of immunology, 40 (8). pp. 2200-2210. ISSN 0014-2980 DOI: https://doi.org/10.1002/eji.201040433

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Abstract

IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10(-/-) mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and enhanced IFN-gamma response in the lung, an increased influx of CD4(+) T cells into the lung, and enhanced production of chemokines and cytokines, including CXCL10 and IL-17, in both the lung and the serum. Neutralization of IL-17 affected neither the enhanced production of CXCL10 nor the accumulation of IFN-gamma-producing T cells in the lungs, but led to reduced numbers of granulocytes in the lung and reduced bacterial loads in the spleens of Mtb-infected mice. This suggests that IL-17 may contribute to dissemination of Mtb.

Item Type: Article
Keywords: Granulocytes, IL-10, IL-17, Mycobacterium tuberculosis, Th1, DRAINING LYMPH-NODES, T-CELL RESPONSES, IMMUNE-RESPONSES, PULMONARY, TUBERCULOSIS, INTERFERON-GAMMA, IN-VIVO, ANTIMYCOBACTERIAL IMMUNITY, INTERLEUKIN-10 RECEPTOR, DENDRITIC CELLS, C57BL/6 MICE
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
PubMed ID: 20518032
Web of Science ID: 281305900019
URI: http://researchonline.lshtm.ac.uk/id/eprint/2931

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